Hageman Disease
Hageman Disease is a factor XII deficiency. This deficiency is inherited in an autosomal recessive fashion.
It has been reported that factor XII levels seem to be lower among Asians than any other ethnic group. The mystery of factor XII centers on how the protein is a step in the process of forming a clot, but people with the deficiency usually do not experience bleeds and normally do not require treatment. Having a low factor XII level has little to no clinical significance. Even with major surgery, bleeding manifestations are extremely rare. Most people are diagnosed by chance or during pre-screening blood tests for surgery.