Fletcher Factor Deficiency
Fletcher Factor Deficiency is a rare blood coagulation abnormality which does not cause bleeding problems and is usually an incidental finding.
It is a deficiency of prekallikrein, an enzyme that acts in the formation of blood clot. It is of importance in the early phase of blood coagulation. Hereditary prekallikrein deficiency conditions are inherited through an autosomal recessive pattern. The deficiency is generally diagnosed when evaluating a prolonged coagulation time with no other explanation and clinical history is negative for a bleeding disorder.